5-MTHF powder
5-Methyltetrahydrofolate, commonly known as 5-MTHF, is the biologically active form of folate, a crucial B vitamin that plays a vital role in numerous bodily functions. Unlike synthetic folic acid, 5-MTHF is readily utilized by the body without the need for conversion, making it highly bioavailable. This essential nutrient is central to the methylation cycle, a fundamental biochemical process involved in DNA synthesis and repair, neurotransmitter production, and detoxification. The 5-MTHF benefits extend to supporting cardiovascular health by regulating homocysteine levels, enhancing cognitive function and mood by aiding in the synthesis of serotonin and dopamine, and bolstering immune function. It is particularly beneficial for individuals with MTHFR gene variations who may have difficulty converting other forms of folate into its active form. Supplementing with 5-MTHF can ensure adequate folate levels, promoting overall health and well-being.
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- 5-MTHF CAS No.: 134-39-4 (for Calcium L-5-Methyltetrahydrofolate)
- Chemical Name: (6S)-5-Methyltetrahydrofolic acid
- Synonyms: L-Methylfolate, (6S)-5-MTHF, Metafolin, L-5-Methyltetrahydrofolate, Levomefolic acid
- CB Number: CB8141416 (Example, this number can vary by specific salt form and database)
- Molecular Formula: C20H25N7O6 (for the acid form)
- Molecular Weight: 459.46 g/mol (for the acid form)
- MDL Number: MFCD00045558 (Example, this number can vary by specific salt form and database)
5-MTHF Manufacturing Process
1. Raw Material Sourcing
Selection and rigorous quality control of initial precursor materials, often folic acid or a derivative.
2. Enzymatic Reduction & Methylation
Catalytic conversion of the precursor using specific enzymes to produce tetrahydrofolate, then methylation to 5-MTHF.
3. Purification & Isolation
Multi-stage purification processes, including chromatography, to remove impurities and isolate pure 5-MTHF.
4. Crystallization & Drying
Crystallization of 5-MTHF for desired purity and particle size, followed by gentle drying to remove solvents.
5. Quality Control & Testing
Comprehensive analytical testing (HPLC, NMR, mass spectrometry) to verify purity, potency, and absence of contaminants.
6. Micronization (Optional)
Further processing to reduce particle size, enhancing solubility and bioavailability of the 5-MTHF powder.
7. Packaging
Packaging of the final 5-MTHF product under controlled conditions to maintain stability and prevent degradation.
8. Storage & Shipment
Proper storage in temperature-controlled environments and careful shipment to preserve the integrity of the 5-MTHF powder.
9. Final Product Delivery
Delivery of high-quality 5-MTHF to clients, ready for their specific applications.
Why Choose Gensei as Your 5-MTHF Supplier?
Choosing Gensei as your 5-MTHF supplier means partnering with a leader dedicated to excellence. We understand the critical role of 5-MTHF benefits in numerous applications, from dietary supplements to pharmaceuticals. Our commitment to rigorous quality control ensures that our 5-MTHF powder is of the highest purity and bioavailability. We leverage advanced manufacturing processes and state-of-the-art analytical testing to guarantee a consistent, premium product. Gensei’s expertise in sourcing and production translates into a reliable supply chain, ensuring you always have access to the finest 5-MTHF powder. Our dedicated customer support team is always ready to assist, providing a seamless experience from inquiry to delivery. With Gensei, you choose a partner that values your success and the well-being of your customers, consistently delivering on the promise of superior quality and efficacy.
Characteristics of 5-MTHF:
- Bioavailable Folate: It is the active form of folate, readily used by the body without metabolic conversion.
- High Purity: Typically supplied as a highly purified powder, often as a calcium salt for stability.
- Water-Soluble: Dissolves well in water, facilitating its use in various formulations.
- Light-Sensitive: Requires protection from light to maintain stability.
- Methyl Donor: Plays a crucial role in methylation reactions throughout the body.
Application Scenarios of 5-MTHF:
- Dietary Supplements: Widely used in multivitamin formulations and standalone folate supplements for general health.
- Prenatal Vitamins: Essential for pregnant women to support healthy fetal development and prevent neural tube defects.
- Neurological Support: Used in supplements targeting mood, cognitive function, and nerve health due to its role in neurotransmitter synthesis.
- Cardiovascular Health: Important for maintaining healthy homocysteine levels, which is vital for cardiovascular well-being.
- Specialty Medical Foods: Incorporated into products for individuals with MTHFR gene polymorphisms or other folate absorption issues.
- Fortified Foods: Potentially used in food fortification, offering a more bioavailable alternative to folic acid.
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FAQs
5-MTHF stands for 5-Methyltetrahydrofolate, which is the active, most bioavailable form of folate (Vitamin B9). Unlike synthetic folic acid, 5-MTHF can be directly utilized by the body without requiring conversion, making it highly effective for various physiological processes.
The 5-MTHF benefits are extensive. It supports DNA synthesis and repair, neurotransmitter production (like serotonin and dopamine), cardiovascular health by regulating homocysteine levels, cognitive function, mood regulation, and overall cellular metabolism.
Folic acid is a synthetic form of folate that requires conversion in the body to become active 5-MTHF. Many people, particularly those with MTHFR gene variations, have difficulty converting folic acid efficiently. 5-MTHF is the already active form, ensuring direct utilization.
Individuals with MTHFR gene mutations, pregnant women, those experiencing mood imbalances, and anyone looking to optimize their methylation processes, cardiovascular health, or general well-MTHF, can benefit from 5-MTHF.
Yes, 5-MTHF is generally considered safe. As an essential nutrient, it is well-tolerated by most individuals. However, it's always advisable to consult a healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking other medications.
The recommended dosage of 5-MTHF varies depending on individual needs and health goals. It can range from 400 mcg to 15 mg or more daily. It's best to follow the guidance of a healthcare professional or the instructions on the product label.
While generally safe, 5-MTHF can potentially interact with certain medications, such as some anti-seizure drugs, methotrexate, and drugs for Parkinson's disease. Always inform your doctor about all supplements you are taking.
5-MTHF powder should be stored in a cool, dark, and dry place, away from direct sunlight and moisture, to maintain its stability and potency. Often, refrigeration is recommended after opening.
Side effects from 5-MTHF are rare and usually mild, possibly including irritability, sleep disturbances, or skin reactions in sensitive individuals at very high doses. These usually subside when the dosage is reduced.
While foods like leafy greens, legumes, and liver contain folate, they are primarily in forms that need to be converted to 5-MTHF. Supplementation with 5-MTHF powder or capsules provides the direct, active form.
