riboflavin 5 phosphate Manufacturer
Riboflavin 5-Phosphate, often referred to as R5P, is the active and coenzymated form of vitamin B2 (riboflavin). Unlike standard riboflavin, this r5p vitamin is directly usable by the body without requiring conversion in the liver, making it highly bioavailable. This crucial form of vitamin B2 plays a central role in numerous metabolic processes. The primary riboflavin 5 phosphate benefits include its involvement in energy production, particularly in the electron transport chain, and its function as a coenzyme in antioxidant pathways. It is essential for cellular growth, fat and protein metabolism, and maintaining healthy eyes and skin. Its superior absorption makes it a preferred ingredient in high-quality nutritional supplements and fortified foods, ensuring maximum physiological impact.
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- CAS No.: 146-17-8
- Chemical Name: Riboflavin 5′-(dihydrogen phosphate)
- Synonyms: Riboflavin 5′-phosphate sodium; R5P; Vitamin B2 phosphate; Flavin mononucleotide sodium salt (FMN sodium salt)
- CB Number: CB8180490
- Molecular Formula: (acid form, sodium salt usually )
- Molecular Weight: 456.34 g/mol (acid form, sodium salt slightly higher)
- MDL Number: MFCD00005080
Riboflavin 5-Phosphate Manufacturing Process
Riboflavin (Vitamin B2) Sourcing
High-purity riboflavin (vitamin B2) is sourced, typically produced through microbial fermentation. This serves as the primary precursor for the synthesis of riboflavin 5-phosphate. Quality control ensures its purity and consistency.
Phosphorylation Reaction
The sourced riboflavin undergoes a phosphorylation reaction, usually involving phosphorylating agents like phosphorus oxychloride. This chemical process adds a phosphate group at the 5-hydroxyl position of the ribityl side chain, forming riboflavin 5-phosphate.
Reaction Quenching & pH Adjustment
After the phosphorylation reaction, the mixture is carefully quenched to stop the reaction and remove excess phosphorylating agent. The pH is then precisely adjusted to optimize the stability and solubility of the newly formed riboflavin 5-phosphate.
Purification & Filtration
Extensive purification stages are implemented to remove impurities, unreacted riboflavin, and by-products. This often involves precipitation, crystallization, and various filtration techniques (e.g., membrane filtration) to achieve high purity of R5P.
Drying & Milling
The purified riboflavin 5-phosphate is carefully dried using specialized methods (e.g., spray drying or vacuum drying) to remove residual moisture. The dried product is then milled to a fine, consistent powder, ensuring uniform particle size for various applications.
Quality Control & Packaging
The final riboflavin 5-phosphate powder undergoes rigorous quality control testing for purity, potency, solubility, heavy metals, and other specifications. Once approved, it is packaged in light-resistant, airtight containers to maintain its stability and extend shelf life before distribution.
Why Choose Gensei as Your Riboflavin 5-Phosphate Supplier?
Choosing Gensei as your Riboflavin 5-Phosphate supplier means partnering with a leading Riboflavin 5-Phosphate manufacturer committed to delivering the highest quality active B2. We understand the critical demand for bioavailable nutrients like R5P vitamin, which directly offers superior riboflavin 5 phosphate benefits for energy metabolism and overall health. Our advanced manufacturing processes ensure unmatched purity, stability, and bioavailability, making our R5P ideal for your most sensitive formulations. We pride ourselves on a robust supply chain and stringent quality control, guaranteeing consistent excellence. With Gensei, you gain a reliable partner dedicated to supporting your product innovation and ensuring your customers receive the full power of this essential r5p vitamin.
Features of Riboflavin 5-Phosphate:
- High Bioavailability: As the active form of vitamin B2 (r5p vitamin), it is readily absorbed and utilized by the body, bypassing the need for metabolic conversion.
- Superior Solubility: More soluble in water than standard riboflavin, making it easier to incorporate into liquid formulations and highly concentrated products.
- Coenzymated Form: Directly participates in critical enzymatic reactions, including energy production and antioxidant defense, delivering direct riboflavin 5 phosphate benefits.
- Enhanced Stability: Offers improved stability compared to free riboflavin in certain applications, especially in solutions.
- Essential for Metabolism: Crucial for carbohydrate, fat, and protein metabolism, and vital for cellular respiration.
Application Scenarios of Riboflavin 5-Phosphate:
- Dietary Supplements: Widely used in high-quality multivitamins, B-complex formulas, and energy-boosting supplements for superior absorption and direct r5p vitamin benefits.
- Functional Foods & Beverages: Incorporated into energy drinks, fortified juices, and functional snacks to enhance nutritional value and provide metabolic support.
- Infant Formulas: Essential for healthy growth and development in infants, ensuring readily available vitamin B2 for their metabolic needs.
- Pharmaceutical Formulations: Utilized in specific medical food products or therapeutic preparations where high bioavailability of vitamin B2 is critical.
- Animal Nutrition: Added to specialized animal feeds to support the metabolic health and growth of livestock and pets, leveraging the full riboflavin 5 phosphate benefits.
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FAQs
Riboflavin 5-phosphate (R5P) is the active, coenzymated form of vitamin B2 (riboflavin). Unlike standard riboflavin, R5P does not need to be converted by the body, making it immediately bioavailable for metabolic functions.
Key benefits include its role in energy production, supporting cellular growth, metabolism of fats and proteins, antioxidant defense, and maintaining healthy vision, skin, and nervous system function.
It is considered superior because it is the "pre-activated" form, meaning the body can use it directly without the enzymatic conversion steps required for regular riboflavin. This leads to better absorption and utilization, especially for individuals with genetic variations affecting vitamin B2 metabolism.
When taken within recommended doses, riboflavin 5-phosphate is generally safe. Excess vitamin B2 is typically excreted in urine, which may cause urine to turn a bright yellow color, a harmless side effect.
Yes, riboflavin 5-phosphate is generally vegan, vegetarian, and allergen-friendly, as it is produced synthetically or through fermentation processes, not typically from animal sources.
R5P is a precursor to flavin adenine dinucleotide (FAD), a critical coenzyme in the electron transport chain, which is the primary pathway for generating cellular energy (ATP).
It is commonly found in high-quality dietary supplements, B-complex vitamins, energy drinks, and certain fortified foods where enhanced bioavailability of vitamin B2 is desired.
While it can be taken with or without food, taking riboflavin 5-phosphate with a meal may enhance its absorption, particularly if the meal contains some fats.
The recommended daily intake of vitamin B2 (riboflavin) varies, but for R5P, dosages often range from 10 mg to 50 mg in supplements, depending on individual needs and product formulation. Always follow product-specific guidance or consult a healthcare professional.
Riboflavin 5-phosphate generally has good stability, especially compared to free riboflavin, making it a preferred choice for liquid supplements and beverages. However, it can still be sensitive to light, so proper packaging is important.
